Mechanism of Action of Tumorigenesis of Anticancer Molecules of Palm Oil Tocotrienols (Elaeis Guieensis Jacq.): A Systematic Review

Palm oil contains vitamin E which comprises two structurally similar compounds namely tocopherols and tocotrienols. For many years considered the best therapy in curing disease, but recent research advances, tocotrienol has been widely used as a powerful several diseases, including cancer. We prepared this article to review analyze role of tocotrienols from palm anticancer molecules their mechanism action process tumorigenesis based on literature PubMed, Scopus, Science Direct, ProQuest databases published 2011 2020, according Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) statement. Nineteen English articles abstracts inclusion criteria, systematically reviewed compiled. The results showed that acts intracellular extracellular targets involved cell signaling pathways suppresses growth various malignancies, breast, lung, prostate, ovarian, liver, brain, colon, pancreatic, myeloma cancers. This shows molecular advantages, positive effect proliferation, apoptosis, angiogenesis, metastasis, inflammation, when working together can function effective agents cancer therapy. tocotrienol-mediated therapeutic could help clinicians design new strategies treatment.